'Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells'. 'Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis'.

Passani LA, Bedford MT, Faber PW, et al.

'Huntingtin interacts with a family of WW domain proteins'.

Faber PW, Barnes GT, Srinidhi J, et al.

^ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (September 1998).

'The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters'.

^ Al Sarakbi W, Sasi W, Jiang WG, Roberts T, Newbold RF, Mokbel K (2009).

'SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability'.

^ Pfister SX, Ahrabi S, Zalmas LP, Sarkar S, Aymard F, Bachrati CZ, Helleday T, Legube G, La Thangue NB, Porter AC, Humphrey TC (June 2014).

^ a b c 'Entrez Gene: SETD2 SET domain containing 2'.

'Identification of the full-length huntingtin- interacting protein p231HBP/HYPB as a DNA-binding factor'.

^ Rega S, Stiewe T, Chang DI, Pollmeier B, Esche H, Bardenheuer W, Marquitan G, Putzer BM (Jul 2001).

'Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase'.

^ Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH, Chen Z (Oct 2005).National Center for Biotechnology Information, U.S. SETD2 belongs to a class of huntingtin interacting proteins characterized by WW motifs. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. SETD2 has been shown to interact with Huntingtin. The SETD2 gene is located on the short arm of chromosome 3 and has been shown to play a tumour suppressor role in human cancer. Depletion of SETD2 increases the frequency of deletion mutations that arise by the alternative DNA repair process of microhomology-mediated end joining. The trimethylation of lysine-36 of histone H3 ( H3K36me3) is required in human cells for homologous recombinational repair and genome stability. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. SETD2 protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. SET domain containing 2 is an enzyme that in humans is encoded by the SETD2 gene. cellular response to DNA damage stimulus.regulation of protein localization to chromatin.microtubule cytoskeleton organization involved in mitosis.positive regulation of interferon-alpha production.regulation of double-strand break repair via homologous recombination.embryonic cranial skeleton morphogenesis.cell migration involved in vasculogenesis.transcription elongation from RNA polymerase II promoter.regulation of transcription, DNA-templated.The recommended size for a header display image is 1200 pixels wide (height to maintain aspect ratio). This image size would be absolutely fine for the photo gallery, but will look slightly poor and perhaps pixelated uploaded as a header image display. So in this particular instance the photo is 425 pixels: Then to see what pixel size it is click into 'Details' and scroll down until you see 'Image' and then 'Dimensions'. This allows you to see the size of the photo file.

If you're unsure of the image quality, a good check is to right click on the image where it is saved on your computer, then click into 'Properties' and the following pop-up will appear on your screen: You do not crop in too much to your image which will distort the pixelation.You are uploading the original photo to your website, not an image copied and saved from another website or social media channel.Your photo has been taken with a good camera and is of a high resolution.To alleviate this problem make sure of the following: the smaller you make the crop the more blurry the image, but higher resolution images can cope better with this. If you've uploaded images to your website yet when viewing them in Preview, or in Live mode, they appear blurry it is likely to be due to a combination of the original picture quality and the size of the crop you have set i.e.

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